Skinactive Glucosamine

Skinactive Glucosamine, Acetyl glucosamine (also known as N-acetyl glucosamine or NAG), is a naturally occurring amino sugar that is found in the body. It is a precursor to hyaluronic acid, which is a substance that helps to keep the skin hydrated and plump. Acetyl glucosamine is also known to have anti-inflammatory and antioxidant properties.

Skinactive Glucosamine is made by reacting glucosamine with acetic acid. The reaction is catalyzed by an enzyme called acetylase. The resulting product is a white to off-white powder that is soluble in water and alcohol.

INCI name: Acetyl Glucosamine

OTher name: N-Acetyl D-Glucosamine
CAS: 7512-17-6
Appearance: White powder

Acetyl glucosamine is a versatile antioxidant that has been proven to effectively reduce visible discolorations, especially in 2-5% concentration. It works best for evening out skin tone when used alongside the B vitamin niacinamide. Additionally, it can help strengthen the skin’s supportive elements and is known for its soothing properties.

One of the unique benefits of acetyl glucosamine is its role as a precursor of hyaluronic acid, aiding the skin in producing its own hyaluronic acid naturally. Hyaluronic acid is crucial for maintaining the skin’s hydration and elasticity.

From a technical standpoint, acetyl glucosamine is an amino-monosaccharide (simple sugar). While pure acetyl glucosamine is considered more prone to stability issues, research indicates that a synthetic or bio-fermented derivative called n-acetyl glucosamine is more stable and highly effective. This is the form used in Paula’s Choice Skincare 10% and 20% niacinamide treatments and RESIST eye cream. This form is also vegan, unlike pure acetyl glucosamine, which is typically derived from shellfish.

Benefits:

  • Moisturizing: Acetyl glucosamine can help to keep the skin hydrated by attracting water to the skin. This can help to improve the appearance of the skin by making it look plumper and more radiant.
  • Anti-inflammatory: Acetyl glucosamine has anti-inflammatory properties. This can help to reduce redness, swelling, and irritation of the skin.
  • Antioxidant: Acetyl glucosamine has antioxidant properties. This means that it can help to protect the skin from damage caused by free radicals.
  • Wrinkle reducing: Acetyl glucosamine has been shown to reduce the appearance of wrinkles by stimulating the production of hyaluronic acid.
  • Skin barrier repair: Acetyl glucosamine can help to repair the skin barrier, which is the outermost layer of the skin that protects it from the environment. This can help to prevent the skin from becoming dry, irritated, and prone to infection.

Skinactive Glucosamine is a versatile ingredient with a number of beneficial properties for the skin. It is a safe and effective ingredient for most people, and it can be used in a variety of cosmetic products.

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