GI-TA

GI-TA,Tranexamic acid, is an innovative and highly effective whitening agent that targets melanin reduction and pigmentation reduction. Traditional whitening agents primarily focus on inhibiting the activity of tyrosinase in melanosomes to reduce melanin production. However, these agents only partially inhibit melanin production and accumulation, and achieving a complete block is challenging.

The whitening mechanism of GI-TA involves the rapid and simultaneous inhibition of tyrosinase activity and melanocyte function, preventing melanin aggregation and blocking the process of melanin deterioration caused by ultraviolet irradiation.

 

INCI name:Tranexamic Acid

Molecular formula: C8H15NO2
Molecular weight: 157.21
CAS:1197-18-8

GI-TA acts as a protease inhibitor, preventing the catalysis of proteases on peptide bond hydrolysis. This inhibition helps to prevent the activity of enzymes such as inflammatory proteases, thus restoring proper functioning of epidermal cells in dark spots and suppressing the melanin-enhancing factor group.

By interrupting the process of melanin formation triggered by ultraviolet irradiation, GI-TA effectively prevents and improves skin pigmentation, leading to the reduction and prevention of dark spots, resulting in improved skin tone and appearance. 

GI-TA has four mechanisms of action that contribute to its whitening effect:

Inhibition of tyrosinase and melanocytes: GI-TA rapidly inhibits the activity of tyrosinase, the enzyme responsible for melanin production. It also blocks the aggregation of melanocytes, the cells that produce melanin. This results in a decrease in the production and aggregation of melanin, which leads to a lighter skin tone.

Reduced accumulation of inflammation-induced melanin: GI-TA can effectively slow the accumulation of inflammation-induced melanin in the deep skin. This is because it inhibits the production of prostaglandins, which are inflammatory molecules that can trigger melanin production.

Prevention of secondary oxidation of melanin: GI-TA can effectively prevent the secondary oxidation of melanin. This is important because oxidized melanin is more visible and can contribute to dark spots and hyperpigmentation.

Reduction of precipitated melanin and promotion of melanin separation: GI-TA can effectively reduce the precipitated melanin and promote the separation of the produced melanin. This results in a lighter skin tone and a more uniform complexion.

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