Cosmetic science has entered the microbiome era. After probiotics and prebiotics made their way into skin formulas, the spotlight is now shifting to postbiotics. Unlike probiotics (live microorganisms) or prebiotics (substrates that feed beneficial bacteria), postbiotics are non-viable bacterial products or metabolic byproducts produced during fermentation. They provide the benefits of microbiome support without the regulatory hurdles of formulating with live cultures. For cosmetic chemists, this makes postbiotics an exciting, stable, and compliant way to address skin immunity and sensitivity.
What Are Postbiotics?
Postbiotics are bioactive molecules produced by bacteria during fermentation. They include:
- Peptides & Enzymes – signaling molecules that modulate skin defenses
- Short-Chain Fatty Acids (SCFAs) – improve barrier function and hydration
- Polysaccharides & Exopolysaccharides – reinforce the extracellular matrix
- Organic Acids (e.g., lactic acid) – mild exfoliation, pH regulation
- Bacterial Lysates (non-viable cells) – immune training effects
These components act directly on keratinocytes and immune cells in the skin, promoting balance and resilience.
Mechanism of Action: How Postbiotics Strengthen Skin
- Barrier Reinforcement – Increase ceramide production and strengthen tight junctions
- Immune Modulation – Teach skin’s immune cells to respond calmly to irritants
- Anti-Inflammatory Benefits – Reduce cytokine release and oxidative stress
- Microbiome Balance – Support beneficial bacteria while preventing dysbiosis
INCI Examples of Postbiotics
- Lactobacillus Ferment Lysate
- Bifida Ferment Lysate
- Saccharomyces Ferment Filtrate
- Lactobacillus Ferment Filtrate
- Bacillus Ferment
Cosmetic Applications
- Sensitive Skin Serums → soothing and barrier-repair actives
- Anti-Aging Creams → protect against inflammaging and ROS damage
- Brightening Treatments → some ferments reduce melanogenesis
- Barrier Repair Balms → restore function in compromised skin
Consumer Benefits
- Calms redness and sensitivity
- Supports skin’s natural defenses
- Enhances hydration and smoothness
- Provides gentle exfoliation and glow
- “Microbiome-friendly” claim for marketing appeal
Internal Link Opportunities
- Prebiotics & Probiotics in Skincare
- Centella Asiatica PDRN
- Anti-Inflammatory Actives for Sensitive Skin
Formulation Tips for Chemists
Postbiotics are generally heat-stable, unlike probiotics. Add in the cool-down phase only if specified by supplier. Pair with prebiotics for a synergistic microbiome approach. Encapsulation can enhance stability of sensitive metabolites Use at 1–5% typical levels, depending on concentration.
Future Outlook
Postbiotics bridge the gap between microbiome science and regulatory compliance. With growing demand for safe, natural, and biotech-inspired actives, they offer a strong innovation path for sensitive skin, barrier repair, and immune balance. Cosmetic chemists who integrate postbiotics into formulations not only keep up with market trends but also deliver science-backed efficacy without formulation headaches.
